10 Questions You Should to Know about linear cutter stapler

The "Linear Cutter Stapler Market" reached a valuation of USD xx.x Billion in , with projections to achieve USD xx.x Billion by , demonstrating a compound annual growth rate (CAGR) of xx.x% from to .

Linear Cutter Stapler Market Segmentation Analysis

Segmentation analysis involves dividing a market into distinct groups based on certain criteria to better understand the needs and preferences of different customer segments. In the linear cutter stapler market, segmentation analysis typically focuses on identifying key segments based on type and application.

Linear Cutter Stapler Market By Type

• Straight Linear Cutter Staplers: These devices are designed for straight-line incisions and stapling in surgical procedures.
• Curved Linear Cutter Staplers: Curved linear cutter staplers are used for procedures requiring curved or angled incisions and stapling.

Linear Cutter Stapler Market By Applications

• General Surgery: Linear cutter staplers find extensive use in various general surgical procedures such as gastrointestinal surgeries, bariatric surgeries, and thoracic surgeries.
• Gynecological Surgery: In gynecological surgeries, linear cutter staplers are employed for procedures like hysterectomy and oophorectomy, offering precise incisions and secure closure.
• Urological Surgery: Linear cutter staplers are utilized in urological surgeries for procedures like nephrectomy and prostatectomy, ensuring efficient tissue management and hemostasis.
• Others: This segment encompasses applications beyond the aforementioned categories, including orthopedic surgeries and cardiovascular surgeries, where linear cutter staplers may have specialized uses.

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Who is the largest manufacturers of Linear Cutter Stapler Market worldwide?

• Purple Surgical
• Victor Medical Instruments
• Volkmann MedizinTechnik
• Bilakhia Group
• Benzgum Medical Technology
• B. Braun
• Frankenman International
• Lotus Surgicals
• Surgnova Healthcare Technologies
• Grena LTD
• SAFÄ°R Health Medical
• Beijing Biosis Healing Biological Technology
• Changzhou Xin Neng Yuan Medical Stapler
• Changzhou Lookmed Medical Instrument
• Transeasy Medical Tech.
• Ningbo Weierkaidi Medical Instrument
• Blue Sail Group
• Changzhou Ankang Medical Instruments
• Jiangsu Brightness Medical Devices
• Jiangsu Ripe Medical Instruments Technology
• Changzhou Kangdi Medical Stapler
• Changzhou Waston Medical Appliance
• Precision Medical Instruments
• Changzhou Haida Medical Equipment
• Beijing Lepu Medical Technology
• Zhejiang Geyi Medical Instrument

Short Description About Linear Cutter Stapler Market:

Key insights provided include market and segment sizes, competitive landscapes, current status, and emerging trends. Additionally, the report offers in-depth cost analyses and supply chain evaluations.

Technological innovations are anticipated to enhance product performance, driving broader adoption across various downstream applications. Furthermore, insights into consumer behavior and market dynamics, including drivers, restraints, and opportunities, furnish vital intelligence for understanding the Linear Cutter Stapler market landscape.

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North America, notably the United States, will retain its pivotal position, wielding considerable influence over the market's trajectory. Developments in the U.S. can profoundly impact the global Linear Cutter Stapler landscape. Forecasts predict substantial growth in North America, propelled by widespread adoption of advanced technologies and the dominance of major industry players.

Europe is also poised to play a significant role, exhibiting impressive Compound Annual Growth Rate (CAGR) throughout the forecast period of -. Despite stiff competition, global recovery trends instill optimism among investors, fueling expectations of increased investments in the sector.

This comprehensive report delves into the global Linear Cutter Stapler market, with a particular focus on North America, Europe, Asia-Pacific, South America, the Middle East, and Africa. It categorizes the market based on manufacturers, geographical regions, product types, and applications.

Which regions are leading the Linear Cutter Stapler Market?

• North America (United States, Canada and Mexico)
• Europe (Germany, UK, France, Italy, Russia and Turkey etc.)
• Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)
• South America (Brazil, Argentina, Columbia etc.)
• Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa) 

This Linear Cutter Stapler Market Research/Analysis Report Contains Answers to your following Questions

• What are the global trends in the Linear Cutter Stapler market? Would the market witness an increase or decline in the demand in the coming years?
• What is the estimated demand for different types of products in Linear Cutter Stapler? What are the upcoming industry applications and trends for the Linear Cutter Stapler market?
• What Are Projections of Global Linear Cutter Stapler Industry Considering Capacity, Production and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply and Consumption? What about imports and Export?
• Where will the strategic developments take the industry in the mid to long-term?
• What are the factors contributing to the final price of Linear Cutter Stapler? What are the raw materials used for Linear Cutter Stapler manufacturing?
• How big is the opportunity for the Linear Cutter Stapler market? How will the increasing adoption of Linear Cutter Stapler for mining impact the growth rate of the overall market?
• How much is the global Linear Cutter Stapler market worth? What was the value of the market In ?
• Who are the major players operating in the Linear Cutter Stapler market? Which companies are the front runners?
• Which are the recent industry trends that can be implemented to generate additional revenue streams?
• What Should Be Entry Strategies, Countermeasures to Economic Impact, and Marketing Channels for Linear Cutter Stapler Industry?

Detailed TOC of Global Linear Cutter Stapler Market Research Report, -

1. Introduction of the Linear Cutter Stapler Market

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• Overview of the Market
• Scope of Report
• Assumptions 

2. Executive Summary

3. Research Methodology of Verified Market Reports

• Data Mining
• Validation
• Primary Interviews
• List of Data Sources 

4. Linear Cutter Stapler Market Outlook

• Overview
• Market Dynamics
• Drivers
• Restraints
• Opportunities
• Porters Five Force Model
• Value Chain Analysis 

5. Linear Cutter Stapler Market, By Product

6. Linear Cutter Stapler Market, By Application

7. Linear Cutter Stapler Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the World 

8. Linear Cutter Stapler Market Competitive Landscape

• Overview
• Company Market Ranking
• Key Development Strategies 

9. Company Profiles

10. Appendix

For More Information or Query, Visit @ https://www.verifiedmarketreports.com/product/linear-cutter-stapler-market/

About Us: Verified Market Reports

Verified Market Reports is a leading Global Research and Consulting firm servicing over + global clients. We provide advanced analytical research solutions while offering information-enriched research studies.

We also offer insights into strategic and growth analyses and data necessary to achieve corporate goals and critical revenue decisions.

Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance using industrial techniques to collect and analyze data on more than 25,000 high-impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

Contact us:

Mr. Edwyne Fernandes

US: +1 (650)-781-

US Toll-Free: +1 (800)-782-

(I) The intra-operative conditions: 10 patients received LCSGD-guided overlap EJS after radical laparoscopic total gastrectomy. Both D2 lymphadenectomy and R0 resection were achieved in these patients. No combined multiple organ resection was performed. There was neither conversion to an open thoracic or abdominal procedure nor conversion to other EJS approaches. The average time from the entry of the LCSGD into the abdominal cavity to the completion of the firing of the stapler was 1.8±0.4 minutes, the average time for manual suturing of the EJS common opening was 14.4±2.1 minutes (mean: 18±2 stitches), and the average operative time was 255±52 minutes. (II) The postoperative outcomes: the time to the first ambulation was 1.9±1.4 days, the average time to the first postoperative exhaust/defecation was 3.5±1.3 days, the average time to a semi-liquid diet was 3.6±0.7 days, and the average postoperative hospital stay was 10.4±4.1 days. All patients were smoothly discharged, without any secondary surgery, bleeding, anastomotic fistula, or duodenal stump fistula. (III) Follow-up: The follow-up lasted 9&#;12 months. No eating disorders or anastomotic stenosis was reported. One patient experienced Visick grade II heartburn, and the condition of the remaining 9 patients was Visick grade I.

Compared with laparoscopic-assisted total gastrectomy (LATG), totally laparoscopic total gastrectomy (TLTG) provides more room for surgical operation, reduces intraoperative blood loss, and dissects more lymph nodes, with smaller incisions and comparable short-term outcomes ( 1 - 3 ). However, TLTG, especially esophagojejunostomy (EJS), requires high surgical skills ( 4 ). EJS is mainly performed using a linear stapler, whereas overlap anastomosis is one of the most popular reconstruction methods for intraperitoneal EJS. Overlap EJS requires neither the use of purse-string sutures nor the insertion of anvils and has a good surgical field. The postoperative EJS is highly safe; in particular, the size of the anastomosis is not limited by the esophageal and jejunal transverse diameters, which effectively avoids anastomotic stenosis after surgery. Since its first description in , overlap EJS has been associated with fewer anastomosis-related complications and satisfactory short-term effectiveness. However, overlap EJS is difficult to perform and involves a long anastomosis time, along with a high risk of creating an esophageal pseudotract. In addition, a large common opening after EJS is associated with more difficult closure, slower anastomosis, and increased surgical risk ( 5 ). Accordingly, our team designed and developed the linear cutter/stapler guiding device (LCSGD) (patent number: .6) ( ). The present study retrospectively analyzed the clinical data of 10 patients with gastric cancer who were admitted to the Third Department of Surgery of the Fourth Hospital of Hebei Medical University during the period from July to November and underwent overlap EJS after radical laparoscopic total gastrectomy under the guidance of LCSGD. We aimed to further clarify the value of LCSGD in this procedure. Through the LCSGD docking nail warehouse and stomach tube, nail warehouse into the esophageal cavity is more convenient and faster. The LCSGD skillfully connects the nail warehouse and the gastric tube, so that the nail warehouse in the abdominal cavity-the guiding device of the linear cutting stapler-the gastric tube pierced out of the esophageal cavity forms an integrated connecting device, and then moves into the esophageal cavity. The head end of the nail warehouse does not contact the esophageal wall, so the formation of the esophageal &#;false passage&#; can be fundamentally avoided. We present the following article in accordance with the STROBE reporting checklist (available at https://jgo.amegroups.com/article/view/10./jgo-23-193/rc ).

The LCSGD was assembled in vitro and then used according to the following steps: an itinerant nurse inserted the gastric tube into the esophagus, and the front end of the gastric tube was slightly pressed into the esophageal stump. The operator was guided to create a small opening next to the esophageal stump (about 1/4 to 1/3 of the stump). The gastric tube extended about 2&#;3 cm from this incision to dock with the LCSGD ( ). Using an electronic needle, the operator created a small opening in the jejunal loop (opposite to the mesentery) 0.5 cm below the esophageal-jejunal mutual fixation site, and the linear cutter/stapler was placed into the abdominal cavity through the upper right trocar. The LCSGD on the reload was docked with the gastric tube through an anterior dock line ( ). The operator then moved the linear cutter/stapler towards the esophageal opening. As the anvil approached the opening at the jejunal loop, it was inserted into the jejunal opening. The linear cutter/stapler continued to move upwards, and the anvil and reload smoothly entered the jejunum and the esophagus, respectively. After their locations had been satisfactorily adjusted, the linear cutter/stapler was closed. The itinerant nurse withdrew the gastric tube upwards for 10&#;15 cm ( ). The operator ensured that the stapler did not clamp the gastric tube, after which they performed the esophageal-jejunal side-to-side anastomosis using the stapler ( ). After anastomosis, both the reload and the LCSGD were withdrawn. How the anastomotic limbs overlap is shown in . Finally, the common opening was sutured manually with absorbable barbed sutures under laparoscope to complete the esophageal jejunal anastomosis. Specific LCSGD usage method is shown in .

Tracheal intubation was performed under general anesthesia. The patient was placed in the supine position, with their legs apart. The head was positioned higher than the feet by 15°&#;30° degrees. The operator stood at the left side of the patient, the assistant at the right side of the patient, and the camera holder between the legs of the patient. A trocar was placed below the umbilicus as a camera port. After the pneumoperitoneum was established, the air pressure was maintained at 12&#;14 mmHg (1 mmHg =0.133 kPa). A total of 4 operating ports were created at the intersections between the left and right midclavicular lines and the upper 2 cm of the umbilical level and at the sites 2 cm below the costal arch of the left and right anterior axillary lines. After the liver was lifted, the domes of the diaphragm were divided longitudinally to below the pericardium to create more surgical space. Stomach mobilization and D2 lymph node dissection were routinely performed. The lower esophagus was fully mobilized for 6&#;8 cm, then the esophagus was transected 2&#;3 cm above the upper edge of the tumor using a linear cutter/stapler. A 4-cm midline incision was made to harvest the specimen, which was immediately observed morphologically or via frozen sections to ensure the upper remnant was safe. Subsequently, routine histopathological examination was performed. The upper jejunum was lifted via the superior incision, and a linear cutter/stapler was used to dissociate the jejunum about 20 cm away from the Treitz ligament. The jejunal mesentery was fully mobilized, then the jejunal side-to-side anastomosis was performed 40&#;50 cm away from the jejunal blind loop. After the reconstruction of the pneumoperitoneum, the esophagus was fixed directly above the diaphragm angle by using a multi-spot suture fixation (overlap method, using W-type suture), and the distal jejunum was fixed behind the lower posterior mediastinal esophagus ( 6 ). The lower remnant of the esophagus was fixed to the blind end of the jejunum (about 6&#;8 cm in length) using absorbable sutures (2&#;3 stitches).

A total of 10 patients received overlap EJS after radical laparoscopic total gastrectomy. Both D2 lymphadenectomy and R0 resection were achieved in these patients. No combined multiple organ resection was performed. No conversion to laparotomy or thoracotomy was required. Overlap EJS was guided by LCSGD in all 10 patients. The reload was successfully inserted into the esophageal lumen after a single attempt, with satisfactory position and angle, and the EJS was able to be immediately performed using the stapler. After the operation, the patient was successfully discharged from the hospital and followed up for 9&#;12 months. The average time from the entry of the linear cutter/stapler into the abdominal cavity to the completion of the firing of the stapler was 1.8±0.4 minutes, the average time for manual suturing of esophageal-jejunal common opening was 14.4±2.1 minutes (mean suturing: 18±2 stitches), and the average operative time was 255±52 minutes.

Discussion

The past decades have witnessed the tremendous development of laparoscopic total gastrectomy with the advances in laparoscopic technology. However, there is no uniform standard for digestive tract reconstruction after laparoscopic total gastrectomy, among which the technical difficulties involved in EJS for surgeons have prevailed. The EJS methods used after TLTG include esophageal-jejunal functional end-to-end anastomosis, π-shaped anastomosis, and overlap anastomosis, which have their own strengths and weakness. There are many ways of digestive tract reconstruction after total gastrectomy, but which surgical method is more suitable for patients with total gastrectomy is still controversial. At present, the ideal digestive tract reconstruction method should have the function of food storage bag and keep the function of food storage bag. It can maintain the patency of the patient&#;s food channel, slow down the speed of food entering the small intestine, avoid the patient&#;s duodenal secretions returning to the esophagus, and accelerate the emptying of the bag food to the small intestine in a gradient. In addition, the implementation of reconstruction requires simple operation, less trauma to patients and less postoperative complications, which is conducive to postoperative rehabilitation of patients. Overlap anastomosis has several advantages: (I) it is an iso-peristaltic anastomosis; (II) it is more beneficial to determine whether the upper remnant is negative after the resection of a tumor invading the tooth line; and (III) folding of the jejunum and the mesangium is not required. However, it has some limitations: (I) due to the narrow field of view at the lower posterior mediastinum, the esophageal wall and jejunal wall need to be frequently stretched or clamped when looking for the optimal site for EJS (7); meanwhile, the positions of the anvil, reload, and esophagus/jejunum need to be repeatedly adjusted under the interference of the liver and diaphragmatic foot, so as to control the volumes of the anastomosis and the common opening. (II) The position of the common opening is high (near or above the level of the diaphragm), and the safety and efficiency of suturing is often reduced when the opening is too large. The relevant surgical risks include the following: (I) there is a risk of forming an &#;esophageal pseudo-tract&#; when the slender anvil enters the esophagus; (II) the length of the distal jejunal remnant is uncertain, and an excessively long remnant can easily render the jejunal blind loop vertical to or folded in the jejunum, showing an inverse &#;L&#; shape, which may increase the risk of the anastomosis at the highest point due to gravity and/or diaphragm obstruction. In view of the operational difficulties and risks in traditional overlap anastomosis, our team has made some optimizations and improvements based on our clinical practice. This article for the first time describes the application of LCSGD in overlap EJS after laparoscopic total gastrectomy.

During the traditional overlap anastomosis, the entry of reload into the jejunal side is usually required to prevent the relatively sharp anvil from piercing the jejunum, which, however, may also bring the relatively thick reload into the jejunal side, leading to a long common opening (8). It is well known that a longer jejunal margin greatly increases the chance and degree of jejunal mucosal exstrophy, thus impacting the quality and speed of closing the common opening. In contrast, the esophageal mucosa will not be significantly turned out because of the volume of the esophageal opening, and therefore a slightly larger esophageal opening will not significantly increase the difficulty in closing the common opening. Furthermore, when a reload enters the esophagus, it has minimal risk of causing an esophageal pseudotract due to its thick and blunt characteristics; in contrast, entry of the anvil into the esophagus has such a risk. Therefore, we used the method of hanging the jejunum (which is used in the multi-spot fixation method) to adjust the length and course of the jejunum, so as to systematically avoid the risk that the anvil pierces the jejunum. In fact, the unusual technique of the reload entering the esophagus and the anvil entering the jejunum has become an excellent option. However, 2 new problems still need to be addressed: (I) The reload and the anvil on the linear cutter/stapler need to enter the esophagus or jejunum almost simultaneously; (II) the thicker and blunt reload need to enter the opening smoothly and quickly at the lower end of the relatively small esophagus. Accordingly, we designed and applied the LCSGD that can be installed on the reload of the linear cutter/stapler.

LCSGD is a soft conical rubber device that can be attached to the head end of the reload. The LCSGD-guided overlap EJS has the following advantages: (I) the reload can be placed into the esophageal cavity more easily and quickly after the LCSGD docks the reload and the gastric tube; (II) due to the insertion-typed connection between the device and the gastric tube, the insertion of the reload and the esophagus are predetermined, and thus subsequent attention can be paid to the placement of the anvil in the jejunum only, which is an extremely easy link. Thus, the anvil and the reload enter the jejunum or esophagus simultaneously. In addition, the reload and the anvil are placed into the esophagus or jejunum at satisfactory positions and angles, which help to reduce esophageal traction, narrow the common opening, reduce the iterations of reload placement into the esophageal lumen, and shorten the operative time; (III) the LCSGD delicately connects the reload and the gastric tube, so that the reload in the abdominal cavity, the LCSGD, and the gastric tube from the esophageal cavity are docked together to form an integrated connection device, which is then moved into the esophageal cavity again, during which the head end of the reload does not contact the esophageal wall, thus avoiding the formation of an esophageal pseudotract; (IV) since the reload and the LCSGD will push the gastric tube towards the oral side when they are successively entering the esophageal lumen and there is no direct contact between the stapler and the gastric tube, any accidental cutting or stapling of the gastric tube by the stapler can be avoided; (V) the anvil can enter the jejunum with the use of the LCSGD. As a result, the jejunal margin at the common opening is very small, and the jejunal mucosal exstrophy will easily appear or can be simply controlled once it occurs, which further lowers the difficulty in suturing the common opening, shortens the time of digestive tract reconstruction, increases the reliability of esophageal-jejunal anastomosis, and ensures the safety of surgery. Notably, the connection length must be ensured when the LCSGD is tightly installed onto the linear cutter/stapler, so as to avoid the guiding device being cut off when anastomosing. The biggest problem in this study is that the connection and removal of the linear cutting stapler and LCSGD need to be performed manually, which increases the operation time. We can study a complete linear cutting stapler containing LCSGD and put it into use.

2. Executive Summary

3. Research Methodology of Verified Market Reports

• Data Mining
• Validation
• Primary Interviews
• List of Data Sources 

4. Linear Cutter Stapler Market Outlook

• Overview
• Market Dynamics
• Drivers
• Restraints
• Opportunities
• Porters Five Force Model
• Value Chain Analysis 

5. Linear Cutter Stapler Market, By Product

6. Linear Cutter Stapler Market, By Application

7. Linear Cutter Stapler Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the World 

8. Linear Cutter Stapler Market Competitive Landscape

• Overview
• Company Market Ranking
• Key Development Strategies 

9. Company Profiles

10. Appendix

For More Information or Query, Visit @ https://www.verifiedmarketreports.com/product/linear-cutter-stapler-market/

About Us: Verified Market Reports

Verified Market Reports is a leading Global Research and Consulting firm servicing over + global clients. We provide advanced analytical research solutions while offering information-enriched research studies.

We also offer insights into strategic and growth analyses and data necessary to achieve corporate goals and critical revenue decisions.

Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance using industrial techniques to collect and analyze data on more than 25,000 high-impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

Contact us:

Mr. Edwyne Fernandes

US: +1 (650)-781-

US Toll-Free: +1 (800)-782-

(I) The intra-operative conditions: 10 patients received LCSGD-guided overlap EJS after radical laparoscopic total gastrectomy. Both D2 lymphadenectomy and R0 resection were achieved in these patients. No combined multiple organ resection was performed. There was neither conversion to an open thoracic or abdominal procedure nor conversion to other EJS approaches. The average time from the entry of the LCSGD into the abdominal cavity to the completion of the firing of the stapler was 1.8±0.4 minutes, the average time for manual suturing of the EJS common opening was 14.4±2.1 minutes (mean: 18±2 stitches), and the average operative time was 255±52 minutes. (II) The postoperative outcomes: the time to the first ambulation was 1.9±1.4 days, the average time to the first postoperative exhaust/defecation was 3.5±1.3 days, the average time to a semi-liquid diet was 3.6±0.7 days, and the average postoperative hospital stay was 10.4±4.1 days. All patients were smoothly discharged, without any secondary surgery, bleeding, anastomotic fistula, or duodenal stump fistula. (III) Follow-up: The follow-up lasted 9&#;12 months. No eating disorders or anastomotic stenosis was reported. One patient experienced Visick grade II heartburn, and the condition of the remaining 9 patients was Visick grade I.

Compared with laparoscopic-assisted total gastrectomy (LATG), totally laparoscopic total gastrectomy (TLTG) provides more room for surgical operation, reduces intraoperative blood loss, and dissects more lymph nodes, with smaller incisions and comparable short-term outcomes ( 1 - 3 ). However, TLTG, especially esophagojejunostomy (EJS), requires high surgical skills ( 4 ). EJS is mainly performed using a linear stapler, whereas overlap anastomosis is one of the most popular reconstruction methods for intraperitoneal EJS. Overlap EJS requires neither the use of purse-string sutures nor the insertion of anvils and has a good surgical field. The postoperative EJS is highly safe; in particular, the size of the anastomosis is not limited by the esophageal and jejunal transverse diameters, which effectively avoids anastomotic stenosis after surgery. Since its first description in , overlap EJS has been associated with fewer anastomosis-related complications and satisfactory short-term effectiveness. However, overlap EJS is difficult to perform and involves a long anastomosis time, along with a high risk of creating an esophageal pseudotract. In addition, a large common opening after EJS is associated with more difficult closure, slower anastomosis, and increased surgical risk ( 5 ). Accordingly, our team designed and developed the linear cutter/stapler guiding device (LCSGD) (patent number: .6) ( ). The present study retrospectively analyzed the clinical data of 10 patients with gastric cancer who were admitted to the Third Department of Surgery of the Fourth Hospital of Hebei Medical University during the period from July to November and underwent overlap EJS after radical laparoscopic total gastrectomy under the guidance of LCSGD. We aimed to further clarify the value of LCSGD in this procedure. Through the LCSGD docking nail warehouse and stomach tube, nail warehouse into the esophageal cavity is more convenient and faster. The LCSGD skillfully connects the nail warehouse and the gastric tube, so that the nail warehouse in the abdominal cavity-the guiding device of the linear cutting stapler-the gastric tube pierced out of the esophageal cavity forms an integrated connecting device, and then moves into the esophageal cavity. The head end of the nail warehouse does not contact the esophageal wall, so the formation of the esophageal &#;false passage&#; can be fundamentally avoided. We present the following article in accordance with the STROBE reporting checklist (available at https://jgo.amegroups.com/article/view/10./jgo-23-193/rc ).

The LCSGD was assembled in vitro and then used according to the following steps: an itinerant nurse inserted the gastric tube into the esophagus, and the front end of the gastric tube was slightly pressed into the esophageal stump. The operator was guided to create a small opening next to the esophageal stump (about 1/4 to 1/3 of the stump). The gastric tube extended about 2&#;3 cm from this incision to dock with the LCSGD ( ). Using an electronic needle, the operator created a small opening in the jejunal loop (opposite to the mesentery) 0.5 cm below the esophageal-jejunal mutual fixation site, and the linear cutter/stapler was placed into the abdominal cavity through the upper right trocar. The LCSGD on the reload was docked with the gastric tube through an anterior dock line ( ). The operator then moved the linear cutter/stapler towards the esophageal opening. As the anvil approached the opening at the jejunal loop, it was inserted into the jejunal opening. The linear cutter/stapler continued to move upwards, and the anvil and reload smoothly entered the jejunum and the esophagus, respectively. After their locations had been satisfactorily adjusted, the linear cutter/stapler was closed. The itinerant nurse withdrew the gastric tube upwards for 10&#;15 cm ( ). The operator ensured that the stapler did not clamp the gastric tube, after which they performed the esophageal-jejunal side-to-side anastomosis using the stapler ( ). After anastomosis, both the reload and the LCSGD were withdrawn. How the anastomotic limbs overlap is shown in . Finally, the common opening was sutured manually with absorbable barbed sutures under laparoscope to complete the esophageal jejunal anastomosis. Specific LCSGD usage method is shown in .

Tracheal intubation was performed under general anesthesia. The patient was placed in the supine position, with their legs apart. The head was positioned higher than the feet by 15°&#;30° degrees. The operator stood at the left side of the patient, the assistant at the right side of the patient, and the camera holder between the legs of the patient. A trocar was placed below the umbilicus as a camera port. After the pneumoperitoneum was established, the air pressure was maintained at 12&#;14 mmHg (1 mmHg =0.133 kPa). A total of 4 operating ports were created at the intersections between the left and right midclavicular lines and the upper 2 cm of the umbilical level and at the sites 2 cm below the costal arch of the left and right anterior axillary lines. After the liver was lifted, the domes of the diaphragm were divided longitudinally to below the pericardium to create more surgical space. Stomach mobilization and D2 lymph node dissection were routinely performed. The lower esophagus was fully mobilized for 6&#;8 cm, then the esophagus was transected 2&#;3 cm above the upper edge of the tumor using a linear cutter/stapler. A 4-cm midline incision was made to harvest the specimen, which was immediately observed morphologically or via frozen sections to ensure the upper remnant was safe. Subsequently, routine histopathological examination was performed. The upper jejunum was lifted via the superior incision, and a linear cutter/stapler was used to dissociate the jejunum about 20 cm away from the Treitz ligament. The jejunal mesentery was fully mobilized, then the jejunal side-to-side anastomosis was performed 40&#;50 cm away from the jejunal blind loop. After the reconstruction of the pneumoperitoneum, the esophagus was fixed directly above the diaphragm angle by using a multi-spot suture fixation (overlap method, using W-type suture), and the distal jejunum was fixed behind the lower posterior mediastinal esophagus ( 6 ). The lower remnant of the esophagus was fixed to the blind end of the jejunum (about 6&#;8 cm in length) using absorbable sutures (2&#;3 stitches).

A total of 10 patients received overlap EJS after radical laparoscopic total gastrectomy. Both D2 lymphadenectomy and R0 resection were achieved in these patients. No combined multiple organ resection was performed. No conversion to laparotomy or thoracotomy was required. Overlap EJS was guided by LCSGD in all 10 patients. The reload was successfully inserted into the esophageal lumen after a single attempt, with satisfactory position and angle, and the EJS was able to be immediately performed using the stapler. After the operation, the patient was successfully discharged from the hospital and followed up for 9&#;12 months. The average time from the entry of the linear cutter/stapler into the abdominal cavity to the completion of the firing of the stapler was 1.8±0.4 minutes, the average time for manual suturing of esophageal-jejunal common opening was 14.4±2.1 minutes (mean suturing: 18±2 stitches), and the average operative time was 255±52 minutes.

Discussion

The past decades have witnessed the tremendous development of laparoscopic total gastrectomy with the advances in laparoscopic technology. However, there is no uniform standard for digestive tract reconstruction after laparoscopic total gastrectomy, among which the technical difficulties involved in EJS for surgeons have prevailed. The EJS methods used after TLTG include esophageal-jejunal functional end-to-end anastomosis, π-shaped anastomosis, and overlap anastomosis, which have their own strengths and weakness. There are many ways of digestive tract reconstruction after total gastrectomy, but which surgical method is more suitable for patients with total gastrectomy is still controversial. At present, the ideal digestive tract reconstruction method should have the function of food storage bag and keep the function of food storage bag. It can maintain the patency of the patient&#;s food channel, slow down the speed of food entering the small intestine, avoid the patient&#;s duodenal secretions returning to the esophagus, and accelerate the emptying of the bag food to the small intestine in a gradient. In addition, the implementation of reconstruction requires simple operation, less trauma to patients and less postoperative complications, which is conducive to postoperative rehabilitation of patients. Overlap anastomosis has several advantages: (I) it is an iso-peristaltic anastomosis; (II) it is more beneficial to determine whether the upper remnant is negative after the resection of a tumor invading the tooth line; and (III) folding of the jejunum and the mesangium is not required. However, it has some limitations: (I) due to the narrow field of view at the lower posterior mediastinum, the esophageal wall and jejunal wall need to be frequently stretched or clamped when looking for the optimal site for EJS (7); meanwhile, the positions of the anvil, reload, and esophagus/jejunum need to be repeatedly adjusted under the interference of the liver and diaphragmatic foot, so as to control the volumes of the anastomosis and the common opening. (II) The position of the common opening is high (near or above the level of the diaphragm), and the safety and efficiency of suturing is often reduced when the opening is too large. The relevant surgical risks include the following: (I) there is a risk of forming an &#;esophageal pseudo-tract&#; when the slender anvil enters the esophagus; (II) the length of the distal jejunal remnant is uncertain, and an excessively long remnant can easily render the jejunal blind loop vertical to or folded in the jejunum, showing an inverse &#;L&#; shape, which may increase the risk of the anastomosis at the highest point due to gravity and/or diaphragm obstruction. In view of the operational difficulties and risks in traditional overlap anastomosis, our team has made some optimizations and improvements based on our clinical practice. This article for the first time describes the application of LCSGD in overlap EJS after laparoscopic total gastrectomy.

During the traditional overlap anastomosis, the entry of reload into the jejunal side is usually required to prevent the relatively sharp anvil from piercing the jejunum, which, however, may also bring the relatively thick reload into the jejunal side, leading to a long common opening (8). It is well known that a longer jejunal margin greatly increases the chance and degree of jejunal mucosal exstrophy, thus impacting the quality and speed of closing the common opening. In contrast, the esophageal mucosa will not be significantly turned out because of the volume of the esophageal opening, and therefore a slightly larger esophageal opening will not significantly increase the difficulty in closing the common opening. Furthermore, when a reload enters the esophagus, it has minimal risk of causing an esophageal pseudotract due to its thick and blunt characteristics; in contrast, entry of the anvil into the esophagus has such a risk. Therefore, we used the method of hanging the jejunum (which is used in the multi-spot fixation method) to adjust the length and course of the jejunum, so as to systematically avoid the risk that the anvil pierces the jejunum. In fact, the unusual technique of the reload entering the esophagus and the anvil entering the jejunum has become an excellent option. However, 2 new problems still need to be addressed: (I) The reload and the anvil on the linear cutter/stapler need to enter the esophagus or jejunum almost simultaneously; (II) the thicker and blunt reload need to enter the opening smoothly and quickly at the lower end of the relatively small esophagus. Accordingly, we designed and applied the LCSGD that can be installed on the reload of the linear cutter/stapler.

LCSGD is a soft conical rubber device that can be attached to the head end of the reload. The LCSGD-guided overlap EJS has the following advantages: (I) the reload can be placed into the esophageal cavity more easily and quickly after the LCSGD docks the reload and the gastric tube; (II) due to the insertion-typed connection between the device and the gastric tube, the insertion of the reload and the esophagus are predetermined, and thus subsequent attention can be paid to the placement of the anvil in the jejunum only, which is an extremely easy link. Thus, the anvil and the reload enter the jejunum or esophagus simultaneously. In addition, the reload and the anvil are placed into the esophagus or jejunum at satisfactory positions and angles, which help to reduce esophageal traction, narrow the common opening, reduce the iterations of reload placement into the esophageal lumen, and shorten the operative time; (III) the LCSGD delicately connects the reload and the gastric tube, so that the reload in the abdominal cavity, the LCSGD, and the gastric tube from the esophageal cavity are docked together to form an integrated connection device, which is then moved into the esophageal cavity again, during which the head end of the reload does not contact the esophageal wall, thus avoiding the formation of an esophageal pseudotract; (IV) since the reload and the LCSGD will push the gastric tube towards the oral side when they are successively entering the esophageal lumen and there is no direct contact between the stapler and the gastric tube, any accidental cutting or stapling of the gastric tube by the stapler can be avoided; (V) the anvil can enter the jejunum with the use of the LCSGD. As a result, the jejunal margin at the common opening is very small, and the jejunal mucosal exstrophy will easily appear or can be simply controlled once it occurs, which further lowers the difficulty in suturing the common opening, shortens the time of digestive tract reconstruction, increases the reliability of esophageal-jejunal anastomosis, and ensures the safety of surgery. Notably, the connection length must be ensured when the LCSGD is tightly installed onto the linear cutter/stapler, so as to avoid the guiding device being cut off when anastomosing. The biggest problem in this study is that the connection and removal of the linear cutting stapler and LCSGD need to be performed manually, which increases the operation time. We can study a complete linear cutting stapler containing LCSGD and put it into use.

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