praziquantel in a reef? - Marine Fish Forums

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ostrow:

A very interesting question!

Metronidazole is a very small molecule that readily permeates all tissues by simple diffusion. I'm not familiar with any pharmacokinetic studies in fish, but suspect that therapeutic amounts of the drug accumulates in the skin and mucous tissues where it is absorbed by incoming theronts that come into contact with it. Same thing happens during the immune response: immobilizing antigens bind to the surface of the parasite as they attempt to settle on the fish. Not sure if it can penetrate trophont cysts, or if it affects trophonts that are present (i.e. encysted) before treatment is started.. The drug itself works by being metabolized and the metabolic products bind to intracellular macromolecules disrupting cellular activity in sensitive protozoans and anaerobic bacteria.

The compound can also be used against tomites by adding to the water - which is commonly recommended, but I would be concerned over possible effects on your system, and in particular anaerobic bacteria in your sand bed or live rock. Also, you need to change your water between treatments. However, this is very common and effective way of using metronidazole for the treatment of Hexamita and Spironucleus in FW systems.

Dose rates with oral chemotherapeutants is always tricky. However, metronidazole has a very wide therapeutic margin (in humans at least!), so your fish should be safe from being overdosed. Try a rate of 2 mg (active drug) per g of food for 5 to 10 days, closely watching your fish. If you do decide to try adding to the water, the dose rate would be 6 mg/L every 3-5 days for 3 treatments.

Reference regarding oral efficacy are cited in Herwig, (Handbook of Drugs and Chemicals Use in the Treatment of Fish Diseases) and Lewbart (Self-Assessment Colour Review of Ornamental Fish).

Let us know how it goes.

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